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Associate Director / Director Of Peptide(J10057)

3-5万
  • 北京昌平区
  • 经验不限
  • 博士
  • 全职
  • 招1人

职位描述

药物合成
岗位职责:
1.Early-Stage Peptide Synthesis & Scale-Up:
oLead synthesis/purification of complex peptides (>50 aa, cyclic, multi-disulfide, non-natural amino acids) for hit-to-lead optimization.
oDevelop scalable processes (SPPS/LPPS) from mg to 100g scale with focus on speed, purity, and cost-efficiency.
oTroubleshoot challenging sequences (e.g., hydrophobic peptides, aggregation-prone motifs).
2.Technology & Platform Innovation:
oSpearhead R&D initiatives for novel peptide modalities:
Antibody-peptide conjugates (APC)
Peptide nucleic acids (PNA)
Stapled peptides, cell-penetrating peptides (CPP), or other advanced scaffolds.
oEvaluate and implement cutting-edge tools (e.g., flow chemistry, AI-assisted design, automated purification).
3.Client Project Leadership:
oServe as primary scientific contact for clients: design synthetic routes, advise on feasibility, and deliver data-rich reports.
oManage timelines for fast-turnaround discovery projects (e.g., 100s of analogs for SAR).
oMeet or exceed client’s expectation
4.Operational Excellence:
oOptimize lab workflows for high-throughput synthesis and purification (HPLC/UPLC).
oOversee analytical characterization (LC-MS, HPLC) and ensure data integrity.
5.Team Development & Strategy:
oMentor chemists in advanced peptide synthesis techniques.
oCollaborate with leader and BDs together to develop business opportunities.
oIdentify new service opportunities and deliver more materials for business development (e.g., PNA synthesis, bioconjugation).
任职要求:
•PhD in Organic/Peptide Chemistry + 4+ years (or MS + 7+ years) in peptide synthesis (CRO/biotech preferred).
•Expertise in synthesizing complex peptides (e.g., long sequences, multi-cyclic peptide synthesis).
•Proven peptide scale-up experience.
•Passion for innovation (e.g., publications/patents in novel peptide chemistries).
•With rich organic synthesis experience.
•Fluent English (written and spoken) for technical client communications, report drafting, and scientific literature synthesis.
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工作地点

北京昌平区保诺科技

职位发布者

俞屹凤/招聘主管

刚刚活跃
立即沟通
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保诺科技是一家国际化生命科学研发公司,专业为生物制药客户提供从靶标识别到III期的一体化药物研发服务。保诺科技在大小分子发现和专利技术平台方面拥有深厚而丰富的治疗专业知识,在大幅度加快客户先导化合物发现项目的进度方面拥有得天独厚的条件。保诺特点:总部位于美国的CRO,并坚持国际标准(包括知识产权保护、安全和人事标准)拥有成功为客户执行一体化生物研发项目良好业绩一个机制灵活的合作伙伴,且有一支位于美国的项目管理团队协助实时沟通开发、快乐、充满激情的美国生物科技公司文化保诺荣誉:国家高新技术企业国际AAALAC认证北京生物医药产业跨越发展工程(G20工程)企业北京科技研究开发机构国际科技合作基地中关村高新技术企业保诺无锡于2020年8月投入使用,拥有hTME-3DX, FBDD, DEL,抗体研发,细胞治疗等国际先进的技术平台。占地面积: 30,000平方米专业服务:药物化学,药理学,发现生物学,药代动力学,药效学,大分子药物研发,制剂学,化学工艺开发。
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