流程建模科学家（工艺开发 外资三大药企）

• CFD, Mixing, and Transport
o Apply CFD or reduced-order mixing models to evaluate vessel geometry, impeller selection, mixing times, local shear, and heat/mass transfer impacts on crystallization outcomes.
o Integrate CFD insights with PBM to anticipate scale-up effects on supersaturation distribution, PSD, and impurity incorporation.
• Crystallization Science & Mechanistic Studies
o Design and execute data-rich experiments on primary/secondary nucleation, growth, agglomeration, and breakage.
o Use in situ PAT (e.g., FBRM, PVM, Raman, mid-FTIR/ReactIR, ATR-UV/Vis, calorimetry) and offline analytics (e.g., XRPD, DSC, TGA, SEM, laser diffraction, dynamic image analysis) to monitor supersaturation, solid form, and PSD evolution.
• Kinetics, PBM & Thermodynamics
o Estimate kinetic parameters for nucleation, growth, agglomeration, and breakage; build and validate PBMs to predict PSD and shape under varying supersaturation and hydrodynamics.
o Apply thermodynamic and phase-equilibrium models (e.g., solubility modeling, activity coefficient methods, metastable zone width) to inform supersaturation and seeding strategies.
• Process Design, Optimization, and Scale-up
o Develop first-principles models to guide seeding policies, cooling or antisolvent addition profiles, and batch vs. continuous mode selection.
o Define robust operating envelopes and support tech transfer to pilot and commercial assets.
• PAT Strategy & Control
o Lead PAT strategy for crystallization: sensor selection, probe placement, calibration, data integrity, and maintenance.
o Develop soft sensors and multivariate models; integrate PAT with control strategies for real-time monitoring of supersaturation, nucleation events, and PSD proxies.
o Collaborate with automation/controls to deploy feedback/feedforward control leveraging PAT data.
• Model-Based Experimentation
o Design targeted experiments to reduce model uncertainty and refine kinetic/thermodynamic mechanisms, minimizing empirical iteration.
• Route, Form, and Downstream Integration
o Partner with solid-state and analytical teams on polymorph landscapes, salt/cocrystal options, and isolation/washing/drying impacts on quality and PSD.
• Digital & Data Science Integration
o Integrate PBM/CFD and thermodynamic models into digital workflows and data historians; collaborate on AI/ML approaches for soft sensing, parameter estimation, and optimization.
• Cross-functional Collaboration & Documentation
o Translate model and PAT insights into process decisions and control strategies; author technical reports and contribute to regulatory documentation related to crystallization and particle attributes.
• Fluent English speaking and writing capability
海外硕士3年以上经验，海外博士可应届